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Antioxidant Proteins play important roles in countering oxidative damage in organisms. Because of time-consuming and highly cost, identifying the Antioxidant Proteins accurately using biological experiment is a challenge task. For these reason, we proposed a model using machine learning algorithms, namedAOPs-SVM , which was developed based on sequence features and support vector machine. The proposed classifier AOPs-SVM obtained 0.68 in sensitivity, 0.985 in specificity, 0.942 in average accuracy, 0.741 in MCC and 0.832 in AUC respectively in the testing dataset via jackknife cross-validation test. It outperformed existing classifiers. The experimental results demonstrate that theAOPs-SVM is an effective classifier and also contributes to the Antioxidant proteins related research.